Four successive breaks of serve followed before Makarova saved seven break points in the crucial eighth game to cause the upset.
Makarova is likely to provide Kerber with a tough challenge on a searing hot day on Court Philippe Chatrier as she arrived at Roland Garros high on confidence, having beaten Agnieszka Radwanska and Dominika Cibulkova on the slow surface this year.
Ekaterina Makarova of Russian Federation, who is ranked 40th, broke twice early on to go into a 6-2 lead. That picture offers the starkest of contrasts with a spectacular 2016 that also brought her major wins in the Australian and U.S. Opens and a runner-up spot at Wimbledon.
No win but no regrets as Alonso returns to F1
Ultimately, Alonso's bid for the win expired, along with his engine, with 21 laps remaining to relegate him to a 24-place finish . After celebrating the win by dumping a bottle of 2 percent milk on his head, Sato said it was a "fantastic race".
Kvitova, a two-time Wimbledon champion, had very little trouble in her return, beating 86th-ranked Julia Boserup of the United States 6-3, 6-2 in 74 minutes.
Petra Kvitova has made a winning return to tennis as she became the first player to reach the second round of the French Open.
Kvitova said: "I think it doesn't really matter how I played but I won". The 31st-seeded Vinci, most famous for ending Williams' hopes of a calendar year Grand Slam by beating her in the semifinals at Flushing Meadows in 2015, lost to Rio Olympics gold medalist Monica Puig 6-3, 3-6, 6-2.
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The bombing killed 22 people, including children. "That is all different layers, different tiers". The terror threat level now indicates that an attack remains highly likely rather than imminent.
Kvitova, a French Open semi-finalist in 2012, will face Bethanie Mattek-Sands or Evgeniya Rodina in the next round.
Kvitova was left fighting to save her career after the attack, admitting her hand was "still not 100%" while speaking to reporters at Roland Garros on Friday.
The year's second Grand Slam tournament begins on the red clay of Roland Garros on Sunday.
Cosmic Dance: NASA Craft Captures Solar Eclipse
So no need to be jealous: SDO may have seen an eclipse that we didn't, but we'll have an even better view in a few months. The moon's crisp horizon is visible out of this view since the moon doesn't have atmosphere to distort the daylight.
Venus Williams, Dominic Thiem and Bernard Tomic will be in action later Sunday.
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