Hidden in a water delivery truck, the bomb exploded near the German Embassy and the Afghan presidential palace in one of the busiest areas in town.
He vowed that the attack would not shake Germany's determination to "support the Afghan regime with the stabilization of their country". Hospitals frantically appealed for blood donation. India and Pakistan condemned the blast.
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Trump began his speech by calling for a moment of silence for the victims of this week's Manchester concert bombing. Another video from the Brussels meeting involving Trump provoked mixed reactions in the region.
Claimed by the Islamic State, the attack targeted Christians en route to St. Samuel the Confessor monastery in Minya, Egypt, and was the latest in a string of attacks against Coptic Christians in Egypt.
Wednesday's statement from Ghani's office says the president said that "the terrorists, even in the holy month of Ramadan, the month of goodness, blessing and prayer, are not stopping the killing of our innocent people".
A police officer said it was hard to say who was the intended target.
According to the preliminary information of the country's Interior Ministry, the explosive device had been planted in a auto used to transport water. At least 50 people may have been killed or wounded in what officials said was a suicide auto bombing.
At least 80 killed, 350 injured in Kabul car bomb explosion
The target was to attack the convoys of the foreign troops, however, unfortunately the maximum causalities were civilians. The Associated Press reports, "The Afghan interior ministry says 64 people were killed and as many as 320 were wounded".
The Islamic State terrorist group has claimed responsibility for Wednesday's terror attack near the diplomatic quarter in downtown Afghanistan's capital Kabul, the Al Mayadeen TV channel said on Twitter.
There was no immediate claim of responsibility.
Ismail Kawasi, spokesman for the public health ministry, said more than 50 wounded people are in Kabul hospitals so far.
Eyewitnesses reported seeing a mushroom cloud engulf the center of the city, while people more than a kilometer away reported windows being shattered from the force of the blast.
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The Times said YouGov acknowledged that its predictions were controversial and allowed for a wide margin of error. YouGov chief executive Stephan Shakespeare said the data could change dramatically between now and June 8.
There are about 8,400 U.S. troops in Afghanistan - a majority of them are involved in training and advising Afghan troops. Officials said at least 25 people were wounded, with a number of civilian vehicles destroyed or badly damaged.
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