"I expected a very tough match, and the first set was very, very important for the rest of the match", said Murray.
In the women's singles action, third seed Simona Halep beat Daria Kasatkina 6-0, 7-5 and set up a last 16 clash with Carla Suarez Navarro. It was very slow and heavy conditions and to be coming back was hard.
Two of them come on Saturday when Andy Murray takes court against Juan Martin Del Potro. The Scot got the better of his rival to win Olympic gold before losing a five-hour marathon in the Davis Cup semi-finals.
Del Potro is one of the most popular players on global tennis circuit and a hero in his homeland of Argentina.
Crestfallen, the 2009 US Open champion rested his hands and head on the net for nearly the entire duration of the changeover before handing Murray the break in the opening game of the second set.
In a titanic first set, Del Potro wasted 4 set points then saved two before Murray pounced when the Argentine star narrowly miscued. "I couldn't believe that set-that I lost that set".
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An English flag was displayed by a section of the Stade de France crowd as the teams entered the field on a balmy evening. French organisers have also switched the order of the anthems which will see home fans sing " God Save the Queen " last.
1994 - The last time three French women reached the fourth round at Roland Garros.
Del Potro was competing at Roland Garros for the first time since 2012 following his injury problems.
Both players then had set points in an epic tie-break before Murray eventually edged it 10-8, and it proved decisive for the remainder of the match.
'I think it's going to be a good match and good experience for me. It's not new. a year ago I had some problems with my groin.
Croatian qualifier Petra Martic upset 17th-seeded Anastasija Sevastova 6-1 6-1 to reach the fourth round of the French Open.
Del Potro, whose groin caused him trouble in the last match, struggled when stretched wide or in hunting down short balls.
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A nine-time French Open champion and the hot favourite to win once again this year, Nadal breezed into the quarter-finals with a straight-sets thrashing of compatriot Roberto Bautista Agut, 6-1 6-2 6-2. "It was tough because he was playing much better than me in the first set".
"When he's playing well, he is one of the best players in the world", Murray commented on Del Potro's performance, adding that playing against the Argentine this early in the Grand Slam tournament is obviously not easy, but can be a very positive thing at the same time.
It was hard to know whether it was cause or effect, but Murray was broadly more calm than he has been for months, and spared his support box some of his more splenetic behaviour.
STAT OF THE DAY: South Africa's Kevin Anderson moved to the top of the service charts with victory over Britain's Kyle Edmund.
Wozniacki missed the 2016 French Open because of an ankle injury.
Anderson twice recovered from a set down to advance 6-7 (6), 7-6 (4), 5-7, 6-1, 6-4 in just under four hours in a duel between two players born in Johannesburg.
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The left-hander blasted 31 winners as he took just 93 minutes to dismiss Uruguayan 22nd seed Pablo Cuevas 6-2 6-2 6-3.
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