Nicolas Otamendi was free in the box to head home a fourth from David Silva's cross - City's crossing was absolutely flawless at times and it certainly could have been more than 6-0 given their dominance and ruthlessness going forward.
Guardiola has been full of praise for Belgium global De Bruyne, who he described as "one of the best players I've ever seen in my life" after the 4-0 Champions League victory over Feyenoord on Wednesday.
The match was over after the first half, as City went into the interval 3-nil up.
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The Hornets set to play against to the team who is now at the second position, Man City. "But he's a guy I encourage to play, not just to score goals. But in other games we will have to find another way to win".
With this result, City has now scored 17 goals unanswered across all competitions, as part of four consecutive victories.
Smiling, De Bruyne, 26, added: "Sergio's not the only one who doesn't get the recognition he deserves".
"Listen I always think he works hard", said Guardiola, of Aguero. "So if you tell me that I will do as well as he has done I will be happy of course".
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Bell is the first Canadian wireless provider to support the LTE network capabilities of the new Apple Watch Series 3. Apple says it's been working with movie studios to bring titles with 4K and HDR to its iTunes store.
Even Philippe Coutinho's first start could not secure the points for Liverpool, who trailed to a Scott Arfield goal before Mohamed Salah equalised with his fifth of the season.
It was a grim afternoon for Watford, and one they'll want to forget immediately.
The summer transfer window was one the craziest we have ever seen.
On their travels in the league so far this season, City have been flawless.
Manchester United 4-0 Everton
Martial gets through on goal as United break, Schneiderlin slides in to tackle, brushing it with his hand to concede a penalty. Henrikh Mkhitaryan, Romelu Lukaku and Anthony Martial scored in the final 10 minutes after Antonio Valencia's thunderbolt.
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