But first-team regulars Romelu Lukaku, Marcus Rashford and Henrikh Mkhitaryan are set to be included in the squad for the game at Old Trafford as Mourinho looks to add to his four successes in the competition.
United advance in the League Cup.
United thrashed Everton 40-0 in their last League game and will carry a lot of positives from the win.
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In 2006, then non-League Burton Albion were drawn against United in the third round of the FA Cup, and shocked England by holding them to a 0-0 draw at home.
"I've said before, it's the same at Villa Park".
It was a professional performance and we played seriously. They just penned them in.
Luke Shaw, Carrick and McTominay are in contention, so too is goalkeeper Sergio Romero. So, between the victory over Birmingham and Fulham in the last round, Burton Albion tied with Sheffield Wednesday and Norwich, and also lost to Leeds 5-0.
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For Burton, defender John Brayford will not play and attacking midfielder William Miller will be ourt with an injury.
The fact Burton view the early weeks of the league season as more important than a trip to Old Trafford highlights the issues with a competition that Mourinho believes could be dispensable. For Carrick and for Ander it is just patience because their time will arrive. It happened to him last season when the team was engaged in four different competitions.
"Their quality shone through with £180million on the pitch, never mind what's on the bench", Burton boss Nigel Clough said. They had a great result at the weekend as well in beating Fulham.
They've also invested in the players in the midfield - because it is Manchester United the money has come into it. They were nearly invited back in by Victor Lindelöf, who allowed Joe Mason in on goal.
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One thing that Man United will be looking to do tonight is give a chance to some of the players who have failed to make the team so far this season, and who want to impress Jose Mourinho. "If I can win it for a fifth time, there is space for one more".
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