He managed to get the mini-break back when Federer made a mistake at 1-1, but Struff himself then netted a volley to go 3-1 behind and could find no way back from there.
At the conclusion of Federer's on-court interview with tennis great John McEnroe, the American asked him to hang around because a "special guest" had a couple of questions for him.
On Tuesday night, he got something different.
When you've got a legend on court at the end of a match at the end of an Australian Open match it's only right that you let him interview Roger Federer but was it Will Ferrell or Ron Burgundy on the mic?
Australian Open 2018: Melbourne's extreme heat set to bite
Last year, the 20-year-old German who is predicted to be a Grand Slam victor lost to eventual runner-up Rafael Nadal in five sets. Tournament director Craig Tiley said the Australian Open was one of the only events in the world to actually have a heat policy.
Belgian seventh seed David Goffin was knocked out in the second round, going down 1-6 7-6 (7-5) 6-1 7-6 (7-4) to 36-year-old Julien Benneteau, the world number 59.
Federer pounced immediately at the start of the second to gain another break and cantered through the rest of the match.
The five-time major victor recovered from an early break in the second set and closed out her 6-1, 6-4 victory over Tatjana Maria with an ace.
The 30-year-old Russian, ranked 61, breezed past Maria 6-1, 6-4 to make the second round.
US government shutdown looms as Senate short of votes for spending bill
The last government shutdown occurred in 2013 when Republican lawmakers unsuccessfully tried to defund the Affordable Care Act. His remarks set the stage for a high-stakes day in which Congress has less than twelve hours to avoid a government shutdown.
"Lindsay is fantastic. We've had three years together and she has taught me how to handle big moments like this", said Keys, who made the Australian Open semis in 2015. "There's TV stuff as well, I don't know what you guys ask for at night". Federer hasn't lost before the third round of a grand slam since the 2013 Wimbledon.
He lost the first set before Monfils began badly wilting in the heat in the second and was heard at one point telling the umpire: "I'm exhausted and dizzy". Halep has another unseeded opponent in Lauren Davis to contend with.
"It's always really cool to go up against the best in the world", Bouchard said. "I mean, they're struggling some way or another".
Unsafe sixth seed Karolina Pliskova also went through, dropping just two games against Beatriz Haddad Maia.
Trump sums up his workout routine: 'I walk, I this, I that'
Trump's cholesterol reading from Friday's exam was borderline high even though he takes a low dose of the statin drug Crestor. The President , famously, does not drink or smoke, citing his late brother's death after a long struggle with alcoholism.
Flying under the radar, the 17th seed has surrendered just 16 games on her way to the fourth round after beating Romania's Ana Bogdan 6-3, 6-4. "But it felt pretty routine today".
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