Right now, the storm is about 220 kilometres south-southwest of Panama City, Florida.
Florida Governor Rick Scott on Tuesday described the storm as a "serious and life-threatening situation" and urged people not to take any chances.
Emergency management officials in Franklin County said everyone should be where they need to be as of 5 p.m.
Michael is forecast to become a category four hurricane before it reaches the coast of Florida. Some areas could see up to 4 inches of rain.
The National Hurricane Center said Michael is the first major storm to hit the Florida Panhandle since Hurricane Dennis in 2005. It is expected to weaken as it moves up into the southeastern United States.
Myers said Hurricane Michael will likely be less destructive than Hurricane Florence, which caused an estimated $60 billion in overall damage and economic impact, because the storm is moving at a faster pace and will likely cause less inland flooding. No one is going to survive that.
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Hurricane-force winds extend outward up to 45 miles (75 km) from the center and tropical-storm-force winds extend outward up to 175 miles (280 km).
Forecasters in Alabama warned of possible tornados.
The sinister-looking skull appeared briefly on the National Oceanic and Atmospheric Administration satellite images on Tuesday as the hurricane moved closer to the Florida Panhandle. Mandatory evacuations were ordered in Wakulla, Franklin, Gulf and Bay counties.
As Hurricane Michael barreled through the Gulf of Mexico toward northwest Florida on Wednesday, unsafe storm surges had already begun flooding the state's vulnerable coastal communities. There is no way to hide from storm surge.
"That means the water will come miles inshore and could easily be over the roofs of houses", Scott said.
Speaking in the Oval Office Donald Trump said: "This started off very innocently a week ago, a small storm".
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Georgia Gov. Nathan Deal declared an emergency for 92 counties.
Other effects of Michael, primarily confined to southeast MA, include the possibility of the seas rising as high as 7 to 11 feet along the south coast and stronger winds on Thursday.
At least 13 people reportedly died in Central America over the weekend as a result of storm rains and floods.
Parts of western Cuba, which was hit by the storm on Monday, were forecast to receive up to a foot of rain.
Offshore energy production has already been affected - with U.S. producers in the Gulf cutting oil production by about 40% on Tuesday.
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The precipitation from Florence will start midday Thursday and then it will rain for four days, said CNN Meteorologist Tom Sater. NASA astronauts used a super wide-angle lens to capture the footage of Hurricane Florence , due to the massive size of it.
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